博士 / 副教授 / 硕士研究生导师

聊城大学“光岳英才计划”

电话：0635-8239773    

邮箱：lywqp@126.com

地址：山东省聊城市湖南路1号，邮政编码：252059

教育及工作背景                          

  2016.07～  今    聊城大学        生物制药研究院/山东省抗体制药协同创新中心/山东省纳米药物与释药系统工程技术研究中心  药物化学

2013.09～2016.06    南开大学    博士学位  药学院  化学生物学

2009.09～2012.06    西南大学    硕士学位  化学院  有机化学

2005.09～2009.06    烟台大学    学士学位  化学院  应用化学   

研究方向                        

 药物化学、化学生物学、药剂学：

1. 抗肿瘤药物分子的理性设计合成、活性及作用机理研究；

2. 靶向型纳米药物的开发及其在药物化学领域的应用；

3. 药物结晶工程、药物晶型筛选。

 承担项目                 

1.山东省自然科学基金重点项目。主持。

2.山东省高等学校青创科技支持计划。主持。

3.国家自然科学基金青年基金。主持。

4.山东省自然科学基金博士基金。主持。

5.山东省抗体制药协同创新中心开放课题。主持。

 论文发表                                                                       

1. 1.Zhang, Ming; Chen, Yan; Liu, Zhifang; Liu, Min; Qingpeng Wang*. Series of Desloratadine Platinum(IV) Hybrids Displaying Potent Antimetastatic Competence by Inhibiting Epithelial−Mesenchymal Transition and Arousing Immune Response. Journal of Medicinal Chemistry, 2024, 67, 2031−2048. (SCI 1区，Top)
2. 2.Yan Chen, Ming Zhang, Yanqin He, Suying Li, Shuaiqi Feng, Zhifang Liu, Ning Zhang, Meifeng Liu, and Qingpeng Wang*. Canadine Platinum(IV) Complexes Targeting Epithelial−Mesenchymal Transition as Antiproliferative and Antimetastatic Agents. Journal of Medicinal Chemistry, 2024, 67, 12868-12886. (SCI 1区，Top)
3. 3. Ming Zhang, Yan Chen, Shuaiqi Feng, Yanqin He, Zhifang Liu, Ning Zhang, and Qingpeng Wang*. Transferrin-Modified Carprofen Platinum(IV) Nanoparticles as Antimetastasis Agents with Tumor Targeting, Inflammation Inhibition, Epithelial−Mesenchymal Transition Suppression, and Immune Activation Properties. Journal of Medicinal Chemistry, 2024, 67(18):16416-16434.(SCI 1区，Top)
4. 4. Yan Chen, Ming Zhang, Zhifang Liu, Ning Zhang, Qingpeng Wang*. Ursodeoxycholic Acid Platinum(IV) Conjugates as Antiproliferative and Antimetastatic Agents: Remodel the Tumor Microenvironment through Suppressing JAK2/STAT3 Signaling. Journal of Medicinal Chemistry, 2024, 67, 19, 17551–17567. (SCI 1区，Top)
5. 5. Linming Li, Yan Chen, Ming Zhang, Suying Li, Shuaiqi Feng, Yan-Qin He, Ning Zhang, Zhifang Liu, Meifeng Liu, Qingpeng Wang*. Hydroxychloroquine Platinum(IV) Conjugate Displaying Potent Antimetastatic Activities by Suppressing Autophagy to Improve the Tumor Microenvironment. Dalton Transactions, 2024, 53(33): 13890-13905. (SCI 2区)
6. 6. Li S, Feng S, Chen Y, Sun B, Zhang N, Zhao Y, Han J, Liu Z, He YQ, Wang Q*. Ciclopirox platinum(IV) conjugates suppress tumors by promoting mitophagy and provoking immune responses. J Inorg Biochem. 2024, 260:112696. (SCI 2区)
7. 7. Ming Zhang, Linming Li, Suying Li, Zhifang Liu, Ning Zhang, Bin Sun, Zhengping Wang, Dianlong Jia, Min Liu, Qingpeng Wang*. Development of clioquinol platinum(IV) conjugates as autophagy targeted antimetastatic agents. Journal of Medicinal Chemistry, 2023, 66(5): 3393-3410. (SCI 1区，Top)
8. 8. Yan Chen, Linming Li, Zhifang Liu, Meifeng Liu*, Qingpeng Wang*. A series of ligustrazine platinum(IV) complexes with potent anti-proliferative and anti-metastatic properties that exert chemotherapeutic and immunotherapeutic effects. Dalton Trans., 2023, 52, 13097–13109.(SCI 2区)
9. 9. Linming Li, Ming Zhang, Dianlong Jia, Zhifang Liu, Ning Zhang, Bin Sun, Zhengping Wang, Min Liu, Qingpeng Wang*. Multi-specific niflumic acid platinum(IV) complexes displaying potent antitumor activities by improving immunity and suppressing angiogenesis besides causing DNA damage. Dalton Transactions. 2023, 52, 147-158. (SCI 2区)
10. 10. Zuojie Li, Linming Li, Wenhuan Zhao, Bin Sun, Zhifang Liu, Min Liu, Jun Han, Zhengping Wang, Dacheng Li, Qingpeng Wang*. Development of a series of flurbiprofen and zaltoprofen platinum(IV) complexes with antimetastasis competence targeting COX-2, PD-L1 and DNA. Dalton Transactions. 2022, 51(33): 12604-12619.  (SCI 2区)
11. 11. Zuojie Li; Qingpeng Wang*; Linming Li; Yan Chen; Jichun Cui; Min Liu; Ning Zhang*; Zhifang Liu*; Jun Han; Zhengping Wang; Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression and Enhanced Immune Response, Journal of Medicinal Chemistry, 2021, 64(24)：17920-17935.(SCI 1区，Top)
12. 12. Linming Li; Yan Chen; Qingpeng Wang*; Zuojie Li; Zhifang Liu; Xuewen Hua; Jun Han; Chunxiao Chang*; Zhengping Wang; Dacheng Li; Albumin-encapsulated Nanoparticles of Naproxen Platinum(IV) Complexes with Inflammation Inhibitory Competence Displaying Effective Antitumor Activities in vitro and in vivo, International Journal of Nanomedicine, 2021, 2021(16)：5513-5529. (SCI 2区)
13. 13. Zhifang Liu, Zuojie Li, Tao Du, Yan Chen, Qing-peng Wang*, Guoshuai Li, Min Liu, Ning Zhang, Dacheng Li, Jun Han. Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(IV) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism. Dalton Transactions, 2021, 50, 362-375. (SCI 2区)
14. 14. Yan Chen, Qingpeng Wang,* Zuojie Li, Zhifang Liu, Yanna Zhao, Junfeng Zhang, Min Liu, Zhengping Wang, Dacheng Li*, Jun Han. Naproxen platinum(IV) hybrids inhibiting cycloxygenases and matrix metalloproteinases and causing DNA damage: synthesis and biological evaluation as antitumor agents in vitro and in vivo. Dalton Trans. 2020, 49, 5192–5204. (SCI 2区)
15. 15. Guoshuai Li, Junfeng Zhang, Zhifang Liu, Qingpeng Wang*, Yan Chen, Min Liu, Dacheng Li*, Jun Han, Bingquan Wang. Development of a series of 4-hydroxycoumarin platinum(IV) hybrids as antitumor agents: Synthesis, biological evaluation and action mechanism investigation. J, Inorg, Biochem., 2019,194, 34–43. (SCI2区，Top)
16. 16. Wang, Q. P.*; Tan, X. X.; Liu, Z. F.; Li, G. S.; Zhang, R. Y.; Wei, J. J.; Wang, S. B.; Li, D. C.*; Wang, B. Q.; Han, J. Design and synthesis of a new series of low toxic naphthalimide platinum(IV) antitumor complexes with dual DNA damage mechanism. Eur. J. Pharm. Sci. 2018, 124, 127–136. (SCI 2区)
17. 17. Tan, X. X.; Li, G. S.; Wang, Q. P.*; Wang, B. Q.; Li, D. C. *; Wang, P. G. Small Molecular Platinum(Ⅳ) Compounds as Antitumor Agents. Prog. Chem. 2018, 30, 831–846. (Review)
18. 18. Jing Ma^#, Qing-Peng Wang^#, Zhong-Lv Huang, Xian-De Yang, Quan-Deng Nie, Wen-Pei Hao, Peng George Wang*, Xin Wang*. Glycosylated platinum(IV) complexes as substrates for glucose transporters (GLUTs) and organic cation transporters (OCTs) exhibited cancer targeting and human serum albumin binding properties for drug delivery. J. Med. Chem. 2017,  60: 5736–5748.（SCI 1区, Top)
19. 19. Qing-Peng Wang, Zhong-Lv Huang, Jing Ma, Xiao-Lin Lu, Li Zhang, Xin Wang*, Peng George Wang*. Design, synthesis and biological evaluation of a series of new glycosylated platinum(IV) complexes as antitumor agents. Dalton Trans. 2016,  45: 10366–10374. (SCI 2区) 
20. 20. Hong-Bo Zhang^#, Qing-Peng Wang^#, Xin Ning, Hang Hang, Jing Ma, Xian-De Yang, Xiao-Lin Lu, Jia-Bao Zhang, Yong-Hong Li, Cong-Wei Niu, Hao-Ran Song, Xin Wang*, Peng George Wang*. Synthesis and biological evaluations of a series of thaxtomin analogues. J. Agric. Food Chem. 2015,  63: 3734–3741.（SCI 1区)

专利申请               

(1).王庆鹏，刘治芳，陈延。一种川芎嗪四价铂类化合物、其制备方法及其用途。中国发明专利. CN202111609792.9

(2).王庆鹏，张明，刘治芳。一种具有氯碘羟喹四价铂结构的化合物、其制备方法及其用途。中国发明专利. 202211403148.0

(3).王庆鹏，刘治芳，李大成. 具有不对称单取代萘酰亚胺四价铂结构的化合物、制备方法及其在制备抗肿瘤药物中的应用. 2019, CN 201910407366.3

(4).王庆鹏，刘治芳，李大成. 一种具有喹啉酮四价铂结构的化合物、制备方法及其在制备抗肿瘤药物中的应用。2019, CN 201910441296.3

(5).王庆鹏，刘治芳，陈延。 一种具有萘普生四价铂结构的化合物、制备方法及其在制备抗肿瘤药物中的应用。2019, CN 201911241592.5

(6).王庆鹏, 李大成, 谭晓晓, 刘治芳, 李国帅. 萘酰亚胺四价铂类化合物、制备方法及其在制备抗肿瘤药物中的应用. 中国发明专利. 2018, CN2018101231