博士、教授、硕士研究生导师

 济南大学博士研究生导师

 聊城大学“光岳英才”

 Tel：0635-8239772 

 Email：liumin2@lcu.edu.cn

教育经历

1991.09–1995.07，青岛科技大学，学士

1998.09–2001.02，北京理工大学，硕士

2004.09–2007.07，浙江大学，博士

研究方向：物理化学、分析化学、药剂学

• 难溶性药物的缓控释研究
• 天然活性成分的包封研究
• 联合药物的协同作用研究

科研项目

靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究，国家自然科学基金，2021-2024，主持

儿茶素类天然生化调节剂-抗癌药物协同体系与蛋白质相互作用的量热学-谱学研究，国家自然科学基金，2015–2018，主持

多糖类药物载体靶向控释的抗癌药物与靶标DNA相互作用的化学热力学研究，国家自然科学基金，2012–2014，主持

核酸自组装纳米结构共加载茶多酚-化疗药物的热力学研究，省自然科学基金，2021-2023，主持

紫杉醇人血白蛋白纳米粒药物制剂的研究与开发，山东省重点研发计划项目，2016–2018，主持

智能响应型药物载体对难溶性抗癌药物的增溶及靶向控释研究，山东省抗体制药协同创新中心开放课题，2018-2020，主持

获奖情况

 2019年，山东省高等学校优秀科研成果二等奖，首位

 2016年，山东省高等学校优秀科研成果三等奖，首位

 2013年，山东省高等学校优秀科研成果二等奖，第二位

 2018年，聊城大学优秀科研成果二等奖，首位

 2017年，聊城大学优秀科研成果二等奖，首位

 2016年，聊城大学优秀科研成果二等奖，首位

论著一览

在国内外有较大影响的专业学术期刊上首位或通讯联系人发表论文80余篇。

(1) Tingting Liu; Min Liu*; Qingying Guo; Yinglin Liu; Yanna Zhao; Yushu Wu; Bin Sun; Qingpeng Wang; Jie Liu; Jun Han; Investigation of binary and ternary systems of human serum albumin with oxyresveratrol/piceatannol and/or mitoxantrone by multipectroscopy, molecular docking and cytotoxicity evaluation, J. Mol. Liq., 2020, 311, 113364 (SCI 2区).

(2) Wenxin Pei; Min Liu*; Yushu Wu; Yanna Zhao; Tingting Liu; Bin Sun; Yinglin Liu; Qingpeng Wang; Jun Han; High payload and targeted release of anthracyclines by aptamer-tethered DNA nanotrains — Thermodynamic and release kinetic study, Eur.J.Pharm.Sci.,2020, 148, 105319 (SCI 2区).

(3) Min Liu*; Tingting Liu; Yabo Shi; Yanna Zhao; Hui Yan; Bin Sun; Qingpeng Wang; Zhengping Wang; Jun Han; Comparative study on the interaction of oxyresveratrol and piceatannol with trypsin and lysozyme: binding ability, activity and stability, Food Funct., 2019, 10: 8182–8194 (SCI 1区).

(4) Qingying Guo; Min Liu*; Yanna Zhao; YushuWu; Jie Liu; Chang Cai; Yabo Shi; Jun Han; Spectroscopic and cytotoxicity studies on the combined interaction of (−)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin, Spectrochim. Acta A, 2019, 222: 117213 (SCI 2区).

(5) Yabo Shi; Min Liu*; Hui Yan; Chang Cai; Qingying Guo; Wenxin Pei; Ruiyan Zhang; Zhengping Wang; Jun Han; Mutual influence of piceatannol and bisphenol F on their interactionwith pepsin: Insights fromspectroscopic, isothermal titration calorimetry and molecular modeling studies, Spectrochim. Acta A, 2019, 206: 384–395 (SCI 2区).

(6) Chang Cai; Min Liu*; Hui Yan; Yanna Zhao; Yabo Shi; Qingying Guo; Wenxin Pei; Jun Han; Zhengping Wang; A combined calorimetric, spectroscopic and molecular dynamic simulation study on the inclusion complexation of (E)-piceatannol with hydroxypropyl-b-cyclodextrin in various alcohol + water cosolvents, J. Chem. Thermodyn., 2019, 132: 341–351 (SCI 2区).

(7) Lixia Yuan; Min Liu*; Yabo Shi; Hui Yan; Jun Han; Liying Liu; Effect of (−)- epicatechin -3- gallate and (–)-epigallocatechin-3-gallate on the binding of tegafur to human serum albumin as determined by spectroscopy, isothermal titration calorimetry, and molecular docking, J. Biomol. Struct. Dyn., 2019, 37: 2776–2788 (SCI 3区).

(8) Min Liu*; Qingying Guo; Yabo Shi; Chang Cai; Wenxin Pei; Hui Yan; Han Jia; Jun Han*; Studies on pH and temperature dependence of inclusion complexes of bisdemethoxycurcumin with b-cyclodextrin derivatives, J. Mol. Struct., 2019, 1179: 336–346 (SCI 4区).

(9) Lixia Yuan; Min Liu*; Bin Sun; Jie Liu; Xilian Wei; Zhengping Wang; Binquan Wang; Jun Han; Calorimetric and spectroscopic studies on the competitive behavior between (−)-epigallocatechin-3-gallate and 5-fluorouracil with human serum albumin, J. Mol. Liq., 2017, 248: 330–339 (SCI 2区).

(10) Lixia Yuan; Min Liu*; Guiqin Liu; Dacheng Li; Zhengping Wang; Bingquan Wang; Jun Han; Min Zhang*; Competitive binding of epigallocatechin-3-gallate and 5-fluorouracil to human serum albumin: A fluorescence and circular dichroism study, Spectrochim. Acta A, 2017, 173: 584–592 (SCI 2区).

(11) Jimin Xie; Min Liu*; Guiqin Liu; Lixia Yuan; Dacheng Li; Zhiping Fan; Zhengping Wang; Bingquan Wang; Jun Han; Thermodynamic difference between protocatechualdehyde and p hydroxybenzaldehyde in aqueous sodium chloride solutions, J. Chem. Eng. Data, 2017, 62: 902–912 (SCI 3区).

(12) Min Liu*; Yan Zheng; Chunmei Wang; Jimin Xie; Bingquan Wang; Zhengping Wang; Jun Han; Dezhi Sun; Meuju Niu; Improved stability of (+)-catechin and (-)-epicatechin by complexing with hydroxypropyl-β-cyclodextrin: Effect of pH, temperature and configuration, Food Chem., 2016, 196: 148–154 (SCI 2区).

(13) Chunmei Wang; Min Liu*; Lixia Yuan; Liping Wang; Dezhi Sun; Zhengping Wang; Dacheng Li; Guiqin Liu; Bingquan Wang; Jun Han; Calorimetric and spectroscopic studies on temperature- and pH-dependent interactions of stimuli-responsive poly (N-isopropyl acrylamide) with piceatannol, J. Chem. Thermodyn., 2016, 98: 186–192 (SCI 2区).

(14) Yan Zheng; Min Liu*; Chunmei Wang; Jimin Xie; Dezhi Sun; Bingquan Wang; Jun Han; Meiju Niu*; Simultaneous determination of enthalpies of dilution and dissociation of protocatechuic acid in aqueous salt solutions by calorimetric measurements, J. Chem. Thermodyn., 2015, 91: 177–185 (SCI 2区) .

(15) Jimin Xie; Min Liu*; Yan Zheng; Chunmei Wang; Bingquan Wang; Jun Han; Dezhi Sun*; Temperature- and pH-induced effects on the volumetric properties and refractive indices for two promising cancer preventive agents being protocatechuic acid and protocatechualdehyde, J. Mol. Liq., 2015, 211: 892–898 (SCI 2区).

专利

(1) 蔡畅; 刘敏; 赵燕娜; 韩军; 一种药物-磷脂/白蛋白复合纳米粒及制备工艺, ZL 201711044667.1

(2) 刘敏; 蔡畅; 赵燕娜; 韩军; 一种双药白蛋白纳米粒及制备工艺, 201910158514.2

(3) 刘敏；吴玉姝；裴文鑫；赵燕娜；韩军； 一种基于热力学指导的加载化疗-光疗联合药物的DNA纳米载药体系，202010672102.3