博士/讲师

 邮箱：zhangyongfang@lcu.edu.cn

 地址：山东省聊城市湖南路1号

 邮政编码：252059

研究方向

物理化学、药剂学：

1、基于层状金属氢氧化物的抗癌药物靶向控释剂型的制备及缓释性能研究

2、靶向抗肿瘤前体药物的合成及其在药物化学领域的应用

教育及工作背景

2019.04-至今，聊城大学生物制药研究院，讲师

2013.09-2018.12，山东大学，化学与化工学院，物理化学专业，博士

2010.09-2013.06，聊城大学，化学与化工学院，物理化学专业，硕士

2006.09-2010.06，聊城大学东昌学院，化生系，化学专业，本科

承担项目

1、山东省自然科学基金，编号：ZR2023QB029。执行期：2024.01-2026.12。主持。

2、山东省抗体制药协同创新中心开放课题，编号：CIC-AD1844。执行期：2020.07-2024.12。主持。

3、聊城大学高层次人次、博士科研启动基金，编号：318051916。执行期：2020.01-2024.12。主持。

代表性论文

1. Yongfang Zhang, Synthesis of (10-hydroxycamptothecin intercalated layered zinc hydroxide nitrate)@liposome nanocomposites for improving drug-release performance. Journal of Molecular Liquids, 2024, 397, 124033. (SCI, 二区)

2. 张用芳，陈爱菊，米玉伟，刘敏，曾涑源. 光催化剂钨酸铋的形貌对罗丹明B吸附行为的热力学研究. 聊城大学学报（自然科学版）, 2024 37（6）87-95.

3. 张用芳, 米玉伟, 刘敏, 曾涑源, 孙德志. 聚乙二醇二羧基醚合成工艺优化. 聊城大学学报（自然科学版）, 2021 34（2） 89-95.

4. Yongfang Zhang, Xiaoxia Yang, Zhenning Lu, Haiping Li, Xiuli Guo, Wanguo Hou. Self-assembly behavior of amphiphilic poly(ethylene glycol)-conjugated 10-hydroxycamptothecin in water and its cytotoxicity assay, Applied Surface Science, 2018, 459, 749–759. (SCI, 二区)

5. Yongfang Zhang, Xiaowen Wu, Yuwei Mi, Haiping Li, Wanguo Hou. Engineering of (10-hydroxycamptothecin intercalated layered double hydroxide)@liposome nanocomposites with excellent water dispersity, Journal of Physics and Chemistry of Solids, 2017, 108, 125–132. (SCI, 三区)

6. Xiang Yu, Yuwei Mi, Zihan Gong, Yongfang Zhang, Lei Wang, and Suyuan Zeng. Generation of ^•OH and ^•O₂⁻ Radicals by a Bi₂O₃‑Nanoparticle/Bi₄O₅Br₂ Type-II Heterojunction for Photocatalytic Degradation of Organic Molecules. ACS Applied Nano Materials, 2024, 7, 5156−5168. (SCI, 二区)

7. Yuwei Mi, Haiping Li, Xiang Yu, Yongfang Zhang, Suyuan Zeng, Lei Wang, Wanguo Hou. One-pot synthesis of Bi2S3/Bi4O5Br2  S-scheme heterojunction hierarchical microbelts with enhanced photocatalytic activity in contaminant degradation. Applied Surface Science, 2024, 655, 159573. (SCI, 二区)

8. Lu Wang, Yushu Wu, Tianxin Weng, Xinyu Li, Xinpeng Zhang, Yanqing Zhang,Lixia Yuan, Yongfang Zhang, Min Liu, Binding of combined irinotecan and epicatechin to a pH-responsive DNA tetrahedron for controlled release and enhanced cytotoxicity, Journal of Molecular Structure., 2023, 1283, 135323.

9. Xiaoxia Yang, Yongfang Zhang, Christina Malichewe, Zhaoyu Shi, Lei Wang, Zhenning Lu, Xiuli. Guo. Chitosan nanoparticle mediated upregulation of microRNA34a expression to suppress the proliferation, migration, invasion of MDA-MB-231 cells. Journal of Drug Delivery Science and Technology, 2019, 52, 1061–1069. (SCI, 三区)