博士、教授、硕士研究生导师

    济南大学博士研究生导师

    山东省优秀研究生导师

    聊城大学“光岳学者”

    Tel: 0635-8239772

    Email: liumin2@lcu.edu.cn

 

 

 

 

1991.09–1995.07，青岛科技大学，学士

1998.09–2001.02，北京理工大学，硕士

2004.09–2007.07，浙江大学，博士   

物理化学、分析化学、药剂学

1. 难溶性药物的缓控释研究

2. 天然活性成分的包封研究

3. 联合药物的协同作用研究 

(1) 基于天然低共熔溶剂的糖基化蛋白-联合多酚防癌纳米复合体的构建及热力学机制研究，国家自然科学基金，2027-2030，主持

(2) 靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究，国家自然科学基金，2021-2024，主持

(3) 儿茶素类天然生化调节剂-抗癌药物协同体系与蛋白质相互作用的量热学-谱学研究，国家自然科学基金，2015–2018，主持

(4) 多糖类药物载体靶向控释的抗癌药物与靶标DNA相互作用的化学热力学研究，国家自然科学基金，2012–2014，主持

(5) 核酸自组装纳米结构共加载茶多酚-化疗药物的热力学研究，省自然科学基金，2021-2023，主持

(6) 紫杉醇人血白蛋白纳米粒药物制剂的研究与开发，山东省重点研发计划项目，2016–2018，主持

(7) 智能响应型药物载体对难溶性抗癌药物的增溶及靶向控释研究，山东省抗体制药协同创新中心开放课题，2018-2020，主持

2026年，聊城大学研究生优秀成果一等奖、优秀硕士学位论文指导教师

2025年，山东省优秀研究生导师

2024年，山东省优秀硕士学位论文指导教师

2023年，山东省研究生创新成果奖指导教师

2022年，聊城大学研究生优秀成果一等奖指导教师

2022年，聊城大学科技进步一等奖，首位

2019年，山东省高等学校优秀科研成果二等奖，首位

   在国内外有较大影响的专业学术期刊上首位或通讯联系人发表论文150余篇，近5年代表性论文如下。

(1) Y. Yang, H. Liu, L. Yuan, Q. Wang, A. Chen, X. Zhang, X. Lu, R. Shi, Y. Zhao, M. Liu*, NADES-mediated glycation of casein with mannose and mannose-oligosaccharides: conformation, antioxidant activity, and antimicrobial activity of gastrointestinal digests, Food Res. Int., 2026, 242: 120181, https://doi.org/10.1016/j.foodres.2026.120181. (SCI 1区, Top)

(2) Y. Yang, X. Qi, L. Yuan, A. Chen, X. Zhang, X. Lu, R. Shi, Y. Zhao, M. Liu*, Enhanced stability and anticancer activity of (-)-epicatechin gallate and procyanidin B2: Synergistic effects of natural deep eutectic solvent-based ovalbumin glycation and non-covalent complexation, Food Chem., 2025, 492: 145587, https://doi.org/10.1016/j.foodchem.2025.145587. (SCI 1区, Top)

(3) Q. Wang, X. Qi, L. Yuan, Y. Yang, Y. Wu, Y. Zhao, Y. Zhang, M. Liu*, Improved emulsifying and foaming properties of ovalbumin and antioxidant activity of (-)-gallocatechin gallate: Effects of ultrasound-assisted glycation based on natural deep eutectic solvents and noncovalent binding, Food Chem., 2025, 469: 142517, https://doi.org/10.1016/j.foodchem.2024.142517. (SCI 1区, Top).

(4) J. Liu, X. Li, Y. Wu, X. Zhang, X. Wang, L. Yuan, Y. Zhao, M. Liu*, A multifunctional DNA tetrahedron for imaging, gene therapy, and chemotherapy-phototherapy combination: Binding affinity and anticancer activity, Int. J. Biol. Macromol., 2024, 280: 135713, https://doi.org/10.1016/j.ijbiomac.2024.135713 (SCI 1区, Top).

(5) X. Qi, L. Yuan, Q. Wang, Y. Zhang, G. Jia, Y. Wu, Y. Zhao, Y. Zhang, M. Liu*, Nanocomplex of (-)-epigallocatechin-3-gallate and glycated ovalbumin based on natural deep eutectic solvents: Binding analysis and functional improvement, LWT-Food Sci. Technol., 2024, 195: 115855, https://doi.org/10.1016/j.lwt.2024.115855. (SCI 1区, Top).

(6) X. Qi, H. Liu, Y. Ren, Y. Zhu, Q. Wang, Y. Zhang, Y. Wu, L. Yuan, H. Yan, M. Liu*, Effects of combined binding of chlorogenic acid/caffeic acid and gallic acid to trypsin on their synergistic antioxidant activity, enzyme activity and stability, Food Chem. X., 2023, 18: 100664, https://doi.org/10.1016/j.fochx.2023.100664. (SCI 1区, Top).

(7) X. Li, Y. Wu, X. Zhang. J. Liu. Y. Zhang, L. Yuan, M. Liu*, Thermodynamic and cellular studies of doxorubicin/daunorubicin loaded by a DNA tetrahedron for diagnostic imaging, chemotherapy, and gene therapy, Int. J. Biol. Macromol., 2023, 251: 126245, https://doi.org/10.1016/j.ijbiomac.2023.126245. (SCI 1区, Top).

(8) Y. Ren, Y. Zhu, X. Qi, H. Yan, Y. Zhao, Y. Wu, N. Zhang, Z. Ding, L. Yuan, M. Liu*, Noncovalent interaction of chlorogenic acid and/or gallocatechin gallate with β-lactoglobulin: Effect on stability and bioaccessibility of complexes and nanoparticles, LWT-Food Sci. Technol., 2023, 175: 114493,    https://doi.org/10.1016/j.lwt.2023.114493. (SCI 1区, Top).

(9) Y. Ren, H. Liu, D. Wang, T. Liu, R. Zhang, Y. Wu, Y. Zhang, J. Han, M. Liu*, Antioxidant activity, stability, in vitro digestion and cytotoxicity of two dietary polyphenols co-loaded by β-lactoglobulin, Food Chem., 2022, 371: 131385, https://doi.org/10.1016/j.foodchem.2021.131385. (SCI 1区, Top).

(10) T. Weng, L. Wang, X. Zhang, Y. Wu, Y. Zhao, Y. Zhang, J. Han, M. Liu*, A pH-sensitive DNA tetrahedron for targeted release of anthracyclines: Binding properties investigation and cytotoxicity evaluation, Int. J. Biol. Macromol., 2022, 223: 766–778, https://doi.org/10.1016/j.ijbiomac.2022.11.086. (SCI 1区, Top).

(1) 一种药物-磷脂/白蛋白复合纳米粒及制备工艺, ZL 201711044667.1

(2) 一种基于热力学指导的加载化疗-光疗联合药物的DNA纳米载药体系，ZL202010672102.3

(3) 一种加载化疗药物-茶多酚联合药物的pH响应型靶向DNA纳米载药体系, ZL202210500634.8

(4) 一种基于热力学指导的用于癌症诊疗一体化的DNA 纳米结构, 202310748614.7

(5) 一种糖基化蛋白复合物及其应用, 202410646094.3

(6) 一种纳米载药系统及其制备方法和应用, 202510748066.7