刘敏
作者:生物制药研究院 发布时间:2020-06-15
博士、教授、硕士研究生导师
济南大学博士研究生导师
山东省优秀研究生导师
聊城大学“光岳学者”
Tel: 0635-8239772
Email: liumin2@lcu.edu.cn
1991.09–1995.07,青岛科技大学,学士
1998.09–2001.02,北京理工大学,硕士
2004.09–2007.07,浙江大学,博士
物理化学、分析化学、药剂学
1. 难溶性药物的缓控释研究
2. 天然活性成分的包封研究
3. 联合药物的协同作用研究
(1) 靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究,国家自然科学基金,2021-2024,主持
(2) 儿茶素类天然生化调节剂-抗癌药物协同体系与蛋白质相互作用的量热学-谱学研究,国家自然科学基金,2015–2018,主持
(3) 多糖类药物载体靶向控释的抗癌药物与靶标DNA相互作用的化学热力学研究,国家自然科学基金,2012–2014,主持
(4) 核酸自组装纳米结构共加载茶多酚-化疗药物的热力学研究,省自然科学基金,2021-2023,主持
(5) 紫杉醇人血白蛋白纳米粒药物制剂的研究与开发,山东省重点研发计划项目,2016–2018,主持
(6) 智能响应型药物载体对难溶性抗癌药物的增溶及靶向控释研究,山东省抗体制药协同创新中心开放课题,2018-2020,主持
2025年,山东省优秀研究生导师
2024年,山东省优秀硕士学位论文指导教师
2023年,山东省研究生创新成果奖指导教师
2022年,聊城大学研究生优秀成果一等奖指导教师
2022年,聊城大学科技进步一等奖,首位
2019年,山东省高等学校优秀科研成果二等奖,首位
在国内外有较大影响的专业学术期刊上首位或通讯联系人发表论文150余篇,近5年代表性论文如下。
(1) Y. Yang, X. Qi, L. Yuan, A. Chen, X. Zhang, X. Lu, R. Shi, Y. Zhao, M. Liu*, Enhanced stability and anticancer activity of (-)-epicatechin gallate and procyanidin B2: Synergistic effects of natural deep eutectic solvent-based ovalbumin glycation and non-covalent complexation, Food Chem., 2025, 492: 145587, https://doi.org/10.1016/j.foodchem.2025.145587. (SCI 1区, Top)
(2) Q. Wang, X. Qi, L. Yuan, Y. Yang, Y. Wu, Y. Zhao, Y. Zhang, M. Liu*, Improved emulsifying and foaming properties of ovalbumin and antioxidant activity of (-)-gallocatechin gallate: Effects of ultrasound-assisted glycation based on natural deep eutectic solvents and noncovalent binding, Food Chem., 2025, 469: 142517, https://doi.org/10.1016/j.foodchem.2024.142517. (SCI 1区, Top).
(3) J. Liu, X. Li, Y. Wu, X. Zhang, X. Wang, L. Yuan, Y. Zhao, M. Liu*, A multifunctional DNA tetrahedron for imaging, gene therapy, and chemotherapy-phototherapy combination: Binding affinity and anticancer activity, Int. J. Biol. Macromol., 2024, 280: 135713, https://doi.org/10.1016/j.ijbiomac.2024.135713 (SCI 1区, Top).
(4) X. Qi, L. Yuan, Q. Wang, Y. Zhang, G. Jia, Y. Wu, Y. Zhao, Y. Zhang, M. Liu*, Nanocomplex of (-)-epigallocatechin-3-gallate and glycated ovalbumin based on natural deep eutectic solvents: Binding analysis and functional improvement, LWT-Food Sci. Technol., 2024, 195: 115855, https://doi.org/10.1016/j.lwt.2024.115855. (SCI 1区, Top).
(5) X. Qi, H. Liu, Y. Ren, Y. Zhu, Q. Wang, Y. Zhang, Y. Wu, L. Yuan, H. Yan, M. Liu*, Effects of combined binding of chlorogenic acid/caffeic acid and gallic acid to trypsin on their synergistic antioxidant activity, enzyme activity and stability, Food Chem. X., 2023, 18: 100664, https://doi.org/10.1016/j.fochx.2023.100664. (SCI 1区, Top).
(6) X. Li, Y. Wu, X. Zhang. J. Liu. Y. Zhang, L. Yuan, M. Liu*, Thermodynamic and cellular studies of doxorubicin/daunorubicin loaded by a DNA tetrahedron for diagnostic imaging, chemotherapy, and gene therapy, Int. J. Biol. Macromol., 2023, 251: 126245, https://doi.org/10.1016/j.ijbiomac.2023.126245. (SCI 1区, Top).
(7) Y. Ren, Y. Zhu, X. Qi, H. Yan, Y. Zhao, Y. Wu, N. Zhang, Z. Ding, L. Yuan, M. Liu*, Noncovalent interaction of chlorogenic acid and/or gallocatechin gallate with β-lactoglobulin: Effect on stability and bioaccessibility of complexes and nanoparticles, LWT-Food Sci. Technol., 2023, 175: 114493, https://doi.org/10.1016/j.lwt.2023.114493. (SCI 1区, Top).
(8) Y. Ren, H. Liu, D. Wang, T. Liu, R. Zhang, Y. Wu, Y. Zhang, J. Han, M. Liu*, Antioxidant activity, stability, in vitro digestion and cytotoxicity of two dietary polyphenols co-loaded by β-lactoglobulin, Food Chem., 2022, 371: 131385, https://doi.org/10.1016/j.foodchem.2021.131385. (SCI 1区, Top).
(9) T. Weng, L. Wang, X. Zhang, Y. Wu, Y. Zhao, Y. Zhang, J. Han, M. Liu*, A pH-sensitive DNA tetrahedron for targeted release of anthracyclines: Binding properties investigation and cytotoxicity evaluation, Int. J. Biol. Macromol., 2022, 223: 766–778, https://doi.org/10.1016/j.ijbiomac.2022.11.086. (SCI 1区, Top).
(10) T. Liu, M. Liu*, H. Liu, Y. Ren, Y. Zhao, H. Yan, Q. Wang, N. Zhang. Z. Ding, Z. Wang, Co-encapsulation of (-)-epigallocatechin-3-gallate and piceatannol/oxyresveratrol in β-lactoglobulin: Effect of ligand-protein binding on the antioxidant activity, stability, solubility and cytotoxicity, Food Funct., 2021, 12: 7126–7144, DOI: 10.1039/d1fo00481f (SCI 1区, Top).
(1) 一种药物-磷脂/白蛋白复合纳米粒及制备工艺, ZL 201711044667.1
(2) 一种基于热力学指导的加载化疗-光疗联合药物的DNA纳米载药体系,ZL202010672102.3
(3) 一种加载化疗药物-茶多酚联合药物的pH响应型靶向DNA纳米载药体系, ZL202210500634.8
(4) 一种基于热力学指导的用于癌症诊疗一体化的DNA 纳米结构, 202310748614.7
(5) 一种糖基化蛋白复合物及其应用, 202410646094.3
(6) 一种纳米载药系统及其制备方法和应用, 202510748066.7