博士 / 副教授

 研究生导师

 邮箱：wuyushu@lcu.edu.cn

教育及工作经历：

2016.07-至今    聊城大学，生物制药研究院，讲师、副教授

2011.09-2016.06    山东大学，分析化学，博士学位  

2007.09-2011.06      山东师范大学，应用化学，学士学位

研究方向：

分子识别与生化分析：

1.DNA纳米技术；

2.活细胞内生物分子准确成像；

3.抗肿瘤药物智能递送；

4.食品中化学污染物高效检测。

教学科研项目情况：

1.山东省自然科学基金项目，ZR2018LB023，2018.04-2020.12，主持

2.山东省高等学校科技计划项目，J18KA071，2018.07-2021.06，主持

3.山东省抗体制药协同创新中心开放课题，CIC-AD1830，2018.01-2020.12，主持

4.聊城大学高层次人才及博士科研启动基金，318051632，2017.8-2019.12，主持

5.国家自然科学基金面上项目，22073039，2021.01-2024.12，参与（第2位）。

6.聊城大学研究生教育优质课程建设项目，LCUKC2204，2022.07-2025.06，主持

代表性论文：

1.Yushu Wu*, Min Wu, Qingpeng Wang, Jun Han, Min Liu*, Closing-upon-repair DNA tetrahedron nanoswitch for FRET imaging the repair activity of 8-oxoguanine DNA glycosylase in living cells, Sensors and Actuators B: Chemical, 2023, 390: 133992. (SCI一区)

2.Yushu Wu*, Min Wu, Min Liu*, Danfeng Wang, Lu Wang, Tianxin Weng, Jun Han, Closing-upon-repair DNA tetrahedron nanoswitch for FRET imaging the repair activity of 8-oxoguanine DNA glycosylase in living cells, Analytica Chimica Acta, 2022, 1196: 339481. (SCI一区)

3.Yushu Wu, Min Liu*, Wenxin Pei, Yanna Zhao, Danfeng Wang, Tingting Liu, Bin Sun, Qingpeng Wang, Jun Han, Thermodynamics, in vitro release and cytotoxity studies on doxorubicin–toluidine blue O combination drugs co-loaded in aptamer-tethered DNA nanostructures, Journal of Molecular Liquids, 2020, 320: 114390. (SCI二区)

4.Xinyu Li^#, Yushu Wu^#, Xinpeng Zhang, Jie Liu, Yanqing Zhang, Lixia Yuan, Min Liu*, Thermodynamic and cellular studies of doxorubicin/daunorubicin loaded by a DNA tetrahedron for diagnostic imaging, chemotherapy, and gene therapy, International Journal of Biological Macromolecules, 2023, 251: 126245. (SCI一区) 

5.Xinpeng Zhang^#, Yushu Wu^#, Xinyu Li, Jie Liu, Yuanyuan Peng, Lixia Yuan, Yanna Zhao, Min Liu*, Imaging multiple DNA repair enzymes in living cells based on framework nucleic acid fluorescence nanoprobe, Microchemical Journal, 2024, 200: 110383. (SCI二区)

6.Wenxin Pei, Min Liu*, Yushu Wu*, Yanna Zhao, Tingting Liu, Bin Sun, Yinglin Liu, Qingpeng Wang, Jun Han, High payload and targeted release of anthracyclines by aptamer-tethered DNA nanotrains — Thermodynamic and release kinetic study, European Journal of Pharmaceutical Sciences, 2020, 148:105319. (SCI二区)

7.Yushu Wu, Lei Wang, Wei Jiang*, Toehold-mediated strand displacement reaction-dependent fluorescent strategy for sensitive detection of uracil-DNA glycosylase activity, Biosensors and Bioelectronics, 2017, 89: 984-988. (SCI一区)

8.Yushu Wu, Ping Yan, Xiaowen Xu, Wei Jiang*, A unique dual recognition hairpin probe mediated fluorescence amplification method for sensitive detection of uracil-DNA glycosylase and endonuclease IV activities, Analyst, 2016, 141: 1789-1795. (SCI二区)

9.Yushu Wu, Lei Wang, Jing Zhu, Wei Jiang*, A DNA machine-based fluorescence amplification strategy for sensitive detection of uracil-DNA glycosylase activity, Biosensors and Bioelectronics, 2015, 68: 654-659. (SCI一区)

授权专利：

1.吴玉姝，吴敏，刘敏，韩军，一种DTNS介导的检测8-OG DNA糖基化酶活性的方法，ZL202111082138.7。

2.刘敏，吴玉姝，裴文鑫，赵燕娜，韩军，一种基于热力学指导的加载化疗-光疗联合药物的DNA纳米载药体系，ZL202010672102.3。