王利利 博士/讲师/执业药师

聊城市高新区“3111”工程优选人才

 邮箱：liliwangmail@163.com

教育及工作经历

2024-06 至 今, 聊城大学, 生物制药研究院, 讲师

2015-07 至 2024-06, 聊城高新生物技术有限公司, 注册部

2020-09 至 2024-06, 济南大学, 化学工程与技术, 博士

2017-09 至 2020-06, 聊城大学, 生物化学与分子生物学, 硕士

2008-09 至 2012-07, 济宁医学院, 药物制剂, 学士

研究方向

难溶性药物增溶策略

固体分散体

纳米晶

科研项目情况

1. 聊城大学博士及高层次人才科研启动基金 318052421，2025.01 至 2027.12,  主持

2. 校企合作项目，K24LD213, 2024.12 至 2026.12，主持

3. 山东省科技型中小企业创新能力提升工程, 2021TSGC1297, 2021.12 至 2023.12, 参与

4. 山东省中央引导地方科技发展资金项目, YDZX20203700002731, 2020.01 至 2023.12, 参与

5. 山东省抗体药物创新创业共同体重大科技项目, GTT2111-CYDW-033, 2021.01 至 2022.10,  参与

6. 重大新药创制”国家科技重大专项, 2017ZX09201-003, 2017.01-2020.12, 参与

代表性论文

Lili Wang, Hengqian Wu, Zhengping Wang, et al. Effects of hypromellose acetate succinate on recrystallization inhibition, miscibility, and dissolution enhancement of baloxavir marboxil solid dispersions[J]. International Journal of Biological Macromolecules,2024, 269: 132050.

Lili Wang, Zhuang Ding, Zhengping Wang, et al. The Development of an Oral Solution Containing Nirmatrelvir and Ritonavir and Assessment of Its Pharmacokinetics and Stability[J]. Pharmaceutics, 2024, 16(1): 109.

Zhuang Ding^#, Lili Wang^#, Yangyang Xing, et al. Enhanced Oral Bioavailability of Celecoxib Nanocrystalline Solid Dispersion based on Wet Media Milling Technique: Formulation, Optimization and In Vitro/In Vivo Evaluation[J]. Pharmaceutics, 2019, 11(7): 328.

王利利, 赵文广, 丁壮等. 卡培他滨对非靶标生物斑马鱼胚胎的发育毒性研究[J]. 生态科学, 2019, 38(04): 85-90+110.

Zhuang Ding, Xiao Wang, Lili Wang, et al. Characterisation of spray dried microencapsules with amorphous lutein nanoparticles: Enhancement of processability, dissolution rate, and storage stability[J]. Food Chemistry. 2022, 383, 132200.

Li, Suye; Zhao, Yanna; Wang, Lili, et al. Evaluation of water induced phase transition of Fexofenadine Hydrochloride during wet granulation process using NIR and DSC techniques[J]. Microchemical Journal, 2021, 169:106497.

Zhuang Ding, TaoTao, Lili Wang, et al. Bioprospecting of Novel and Bioactive Metabolites from Endophytic Fungi Isolated from Rubber Tree Ficus elastica Leaves[J]. Journal of microbiology and biotechnology, 2019, 29(5), 731-738.

Hengqian Wu, Zhengping Wang, Yanna Zhao, Yan Gao, Lili Wang, Heng Zhang, Rupeng Bu, Zhuang Ding, Jun Han, Effect of Different Seed Crystals on the Supersaturation State of Ritonavir Tablets Prepared by Hot-Melt Extrusion[J]. European Journal of Pharmaceutical Sciences. 2023, 185.

Hengqian Wu, Zhengping Wang, Yanna Zhao, Yan Gao, Heng Zhang, Lili Wang, Zhe Wang, Jun Han, Effect of Span 20 Feeding Zone in the Twin Screw Extruder on the Properties of Amorphous Solid Dispersion of Ritonavir[J]. Pharmaceutics. 2023, 15.

专利：

(1) 丁壮; 王正平; 韩军; 王晓; 王利利 ; 一种叶黄素微胶囊及其制备方法和应用, 2025-2, 中国,

ZL2023 10002184.4

(2) 王正平; 韩军; 赵文广; 高岩; 王利利 ; 一种靶向诱导的医药分子结构生成方法, 2024-01-09, 中国, ZL 2023 1 1359357.4

(3)韩军; 王利利; 王正平 ; 一种含有奈玛特韦和利托那韦的液体制剂及其制备方法, 2023-2-8, 中国,CN202310081761.3 (实质审查)

(4) 韩军; 王利利; 王正平; 丁壮; 魏其鹏 ; 一种无定型玛巴洛沙韦组合物及其制备方法和药物制剂, 2022-12-30, 中国, CN202211724251.5 (实质审查)