博士 / 副教授/硕士生导师

  聊城大学“光岳新秀”人才支持计划

  聊城大学生物制药研究院“人才支持计划”

  聊城市高新区“3111”工程高端人才

  邮箱：zhaoyanna@lcu.edu.cn

研究方向：

注射/眼用纳米给药系统；难溶性药物增溶；热熔挤出技术

教育及工作经历：

• 2021/01-至今，聊城大学，生物制药研究院，副教授
• 2016/07-2021/01，聊城大学，生物制药研究院，讲师
• 2011/09-2016/07，中国医学科学院＆北京协和医学院，医学博士
• 2007/09-2011/07，山东大学，理学学士 

教学科研项目情况：

§ 国家自然科学基金委员会，面上项目，22073039，靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究，2021/01-2024/12，参与

§ 国家自然科学基金委员会，面上项目，32172901，基于JAK/STAT通路研究硒化刺五加多糖对肉鸡肠道巨噬细胞极化的干预作用，2022/01-2025/12，参与

§ 山东省自然科学基金项目，ZR2017BH065，基于新型“高效稳定剂”，集光疗、化疗于一体的靶向双功能性纳米粒的构建及评价， 2017/08-2019/12，主持

§ 山东省高等学校科技计划项目，J17KA234，集光疗-化疗于一体的双功能性无载体纳米粒的设计评价及产品开发，2017/07-2019/07，主持

§ 山东省抗体制药协同创新中心开放课题，CIC-AD1831，基于白蛋白构建的光疗-化疗双功能性纳米粒用于肿瘤的协同治疗，2018/01-2020/12，主持

§ 横向课题，K20LD39，高稳定性肿瘤肠内全营养乳剂检测方法开发和样品检测，2020/11-2022/11，主持

§ 聊城大学研究生教育教学改革研究项目，“产学研平台”建设下的研究生《现代药理学》课程教学改革与实践，2019/10-2021/10，主持

代表性论文：

（1）Qingran Guan, Qisan Ma, Yanna Zhao*, Xinxin Jiang, Huaizhen Zhang, Min Liu, Zhengping Wang, Jun Han. Cellulose derivatives as effective recrystallization inhibitor for ternary ritonavir solid dispersions: In vitro-in vivo evaluation. Carbohydr Polym, 2021, 273, 118562. (SCI 1区, IF=9.381, TOP)

（2）Yanna Zhao, Chang Cai, Min Liu*, Yuping Zhao, Yushu Wu, Zhiping Fan, Zhuang Ding, Huaizhen Zhang, Zhengping Wang, Jun Han. Drug-binding albumins forming stabilized nanoparticles for co-delivery of paclitaxel and resveratrol: In vitro/in vivo evaluation and binding properties investigation. Int J Biol Macromol, 2020, 153, 873-882. (SCI 1区)

（3）Xinxin Jiang, Yanna Zhao*, Qingran Guan, Shanshan Xiao, Weimiao Dong, Shipeng Lian, Huaizhen Zhang, Min Liu, Zhengping Wang, Jun Han*. Amorphous solid dispersions of cyclosporine A with improved bioavailability prepared via hot melt extrusion: Formulation, physicochemical characterization, and in vivo evaluation. Eur J Pharm Sci, 2022, 168, 106036. (SCI 2区)

（4）Yanna Zhao, Xinxin Jiang, Qisan Ma, Yuping Zhao, Huaizhen Zhang, Qingpeng Wang, Zhuang Ding, Min Liu*, Zhengping Wang, Jun Han. High payload nanoparticles composed of 7-ethyl-10-hydroxycamptothecin and chlorin e6 for synergistic chemo-photodynamic combination therapy. Dyes Pigments, 2021, 184, 108819. (SCI 2区)

（5）Yanna Zhao*, Yuping Zhao, Qisan Ma, Huaizhen Zhang, Yinglin Liu, Jingyi Hong, Zhuang Ding, Min Liu*, Jun Han. Novel carrier-free nanoparticles composed of 7-ethyl-10-hydroxycamptothecin and chlorin e6: Self-assembly mechanism investigation and in vitro/in vivo evaluation, Colloids Surf B Biointerfaces, 2020, 188, 110722. (SCI 2区)

（6）Qisan Ma, Yanna Zhao*, Qingran Guan, Yuping Zhao, Huaizhen Zhang, Zhuang Ding, Qingpeng Wang, Yushu Wu, Min Liu & Jun Han* Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy, Drug Delivery, 2020, 27:1, 1656-1666. (SCI 2区)

（7）Yuping Zhao^#, Yanna Zhao^#,*, Qisan Ma, Bin Sun, Qingpeng Wang, Zhuang Ding, Huaizhen Zhang, Xiuling Chu, Min Liu, Zhengping Wang, Jun Han*. Carrier-Free, Dual-Functional Nanorods via Self-Assembly of Pure Drug Molecules for Synergistic Chemo-Photodynamic Therapy. Int J Nanomed, 2019, 14, 8665-8683. (SCI 2区)

（8）Yanna Zhao, Chang Cai, Min Liu*, Yuping Zhao, Wenxin Pei, Xiuling Chu, Huaizhen Zhang, Zhengping Wang, Jun Han*. An organic solvent-free technology for the fabrication of albumin-based paclitaxel nanoparticles for effective cancer therapy. Colloids Surf B Biointerfaces, 2019, 183, 110394. (SCI 2区)

（9）Yanna Zhao, Xuemei Xie, Yuping Zhao, Yan Gao, Chang Cai, Qinxiu Zhang, Zhuang Ding, Zhiping Fan, Huaizhen Zhang, Min Liu*, Jun Han*. Effect of plasticizers on manufacturing ritonavir/copovidone solid dispersions via hot-melt extrusion: Preformulation, physicochemical characterization, and pharmacokinetics in rats. Eur J Pharm Sci, 2019, 127, 60–70. (SCI 2区)

（10）Qinxiu Zhang, Yanna Zhao*, Yuping Zhao, Zhuang Ding, Zhiping Fan, Huaizhen Zhang, Min Liu, Zhengping Wang, Jun Han*. Effect of HPMCAS on recrystallization inhibition of nimodipine solid dispersions prepared by hot-melt extrusion and dissolution enhancement of nimodipine tablets. Colloids Surf B Biointerfaces, 2018, 172, 118–126. (SCI 2区)

（11）Yifei Guo^#, Yanna Zhao^#, Ting Wang, Ran Li, Meihua Han, Zhengqi Dong, Chunyan Zhu*, and Xiangtao Wang*. Hydroxycamptothecin Nanorods Prepared by Fluorescently Labeled Oligoethylene Glycols (OEG) Codendrimer: Antitumor Efficacy in Vitro and in Vivo. Bioconjugate Chem, 2017, 28 (2), 390–399. (SCI 2区)

（12）Yifei Guo^#, Yanna Zhao^#, Ting Wang, Shuang Zhao, Hanhong Qiu, Meihua Han and Xiangtao Wang*. Honokiol nanoparticles stabilized by oligoethylene glycols codendrimer: in vitro and in vivo investigations. J Mater Chem B, 2017, 5, 697-706. (SCI 2区)