温敏
中国海洋大学食品科学博士
硕士研究生导师
国家注册营养师（RD）

2017.07-至今       聊城大学 生物制药研究院

2012.09-2017.06    中国海洋大学， 食品科学博士

2008.09-2012.06    济南大学，理学学士     

主要从事食品功效成分挖掘与分子营养学研究：

近期主要致力于：（1）基于肠-X轴探究疾病分子机制及营养干预策略（如阿尔茨海默症、睡眠障碍等）；（2）犬猫精准营养需求研究，犬猫源益生菌挖掘及产业化。

1. 山东省营养学会特殊食品专委会委员

2. 山东省营养学会营养科学研究专委会常务委员

3. 乖宝宠物食品集团股份有限公司，科技副总

4. 目前担任Food Funct., MDPI旗下食品营养相关领域期刊审稿人。

1.国家自然科学基金，No.22508158，2026/01-2028/12，主持。

2.山东省自然科学青年基金，ZR2021QH022，2022/01-2024/12，主持。

3. 山东省抗体制药协同创新中心开放课题，CIC-AD1842，2018/1-2020/12，主持。

4. 山东省重点研发计划（医用食品专项计划），2018YYSP008，2018.01-2020.12 参与。

5. 聊城大学博士及高层次人才科研启动基金，318051827，2017/12-2020/12，主持。

6.校企合作项目，318/K20LD0901，2020/01-2021/12；318/K22LD52，2022/01-2023/12，318/K24LD105，主持。

7. 聊城大学畜牧学学科开放课题-创新项目，319462207-24，2023.01-2023.12，主持。

已公开发表SCI论文20余篇，申请发明专利2项。代表性研究成果发表在 J Agric Food Chem.，Food Funct.，Food Science and Human Wellness，Molecular Nutrition & Food Research.等权威食品营养期刊。近5年发表代表性文章如下：

[1] Gong X, Wang X, Chen L, Huang H, Wen M. Integrative genomic and functional characterization of a feline milk-derived Lactiplantibacillus plantarum MNN reveals host-specific adaptation and ecological safety. Front Microbiol. 2026 Jan 21;17:1742444. （中科院二区，IF= 4.5）

[2] Gong X, Wang X, Huang H, Han J, Wang Z, Wen M. A Feline Milk-Drived Pediococcus acidilactici M22 Alleviates Escherichia coli O157:H7 Infection Through Anti-Adhesion, Anti-Inflammation, and Microbiota Modulation. Microorganisms. 2026 Jan 30;14(2):332.

[3] Yueqi Yang, Xueyan Wang, Lu Chen, Ning Zhang, Shilei Ji, Zhengping Wang, Jun Han, Yuming Wang, Min Wen. Exogenous ketogenic supplements can mitigate the susceptibility to Alzheimer’s disease induced by chronic sleep deprivation: emerging role of Sirt1 in ferroptosis. Food Science and Human Wellness, 2025, 14(3): 9250067.(中科院一区，IF=5.6)

[4] Chen, L.; Yang, Y.; Zhang, N.; Sun, B.; Che, H.; Wang, Z.; Han, J.; Wen, M., DHA and EPA protect against cognitive impairment induced by chronic sleep deprivation through regulating iron-mitophagy homeostasis. Food Science and Human Wellness, 2025. https://doi.org/10.26599/FSHW.2024.9250443

[5] Gong X, Wang X, Chen L, Wang Z, Han J, Wen M. Isolation, probiotic properties, and whole-genome analysis of P. acidilactici M22 from feline milk: a promising candidate for simulated pet milk formulations. Front Microbiol. 2025 Aug 29;16:1664636.

[6] Gong X, Wang X, Chen L, Huang H, Zhang N, Han J, Wang Z, Wen M. The Prophylactic Protection of P. acidilactici M22 from Feline Milk on S.Typhimurium Infection in Mice. Microorganisms. 2025 Oct 14;13(10):2353.

[7] Chen, L., Yang, Y., Zhang, N., Che, H., Wang, Z., Han, J., & Wen, M. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis.Free radical biology & medicine, 2024, 225, 654–664. (中科院二区，IF=7.1)

[8] Yang, Y.; Chen, L.; Zhang, N.; Zhao, Y.; Che, H.; Wang, Y.; Zhang, T.; Wen, M., DHA and EPA alleviate epileptic depression in PTZ-treated young mice model by inhibiting neuroinflammation through regulating microglial M2 polarization and improving mitochondrial metabolism. Antioxidants (Basel, Switzerland) 2023, 12 (12).(中科院二区，IF=7)

[9] Yang, Y.; Wang, X.; Chen, L.;Yueqi Yang; Xueyan Wang; Aiai Xiao; Jun Han; Zhengping Wang; Min Wen M. Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer’s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway, Frontiers in Aging Neuroscience. 2022, 14: 998292-998304（中科院二区，IF=4.8）

[10]Wen M, Zhao Y, Shi H, Wang C, Zhang T, Wang Y, Xue C. Short-term supplementation of DHA as phospholipids rather than triglycerides improve cognitive deficits induced by maternal omega-3 PUFA deficiency during the late postnatal stage. Food & Function. 2021, 21;12(2):564-572.（中科院一区，IF=6.1）

[11]Wen M, Ding L, Zhang L, Zhang T, Teruyoshi Y, Wang Y, Xue C. Eicosapentaenoic Acid-Enriched Phosphatidylcholine Mitigated Aβ1-42-Induced Neurotoxicity via Autophagy-Inflammasome Pathway. Journal of Agricultural and Food Chemistry. 2019, 11;67(49):13767-13774.（中科院一区，IF=6.1）

[12]Wen M, Ding L, Zhang L, Cong P, Zhang T, Xu J, Chang Y, Wang Y, Xue C . A comparative study of eicosapentaenoic acid enriched phosphatidylcholine and ethyl ester in improving cognitive deficiency in Alzheimer's disease model rats. Food & Function. 2018, 25;9(4):2184-2192.（中科院一区，IF=6.1）