博士/副教授/研究生导师

聊城大学“光岳英才计划”

邮箱：zhangning1111@126.com

地址：山东省聊城市湖南路1号

邮政编码：252059

教育及工作经历

◾2017/01-至今，聊城大学，生物制药研究院

◾2011/11-2015/11，Stiftung Tierärztliche Hochschule Hannover, Center for Systems Neuroscience，神经科学博士

◾2008/09-2011/07，吉林大学，理学学士

研究方向

（1）神经退行性疾病，如多发性硬化症和阿尔茨海默病的神经炎症、神经免疫及髓鞘再生机制的研究

（2）高脂低碳饮食疗法和功能性食品有效成分的抗肿瘤活性及机制的研究

（3）特殊医学用途配方食品组方研发及申报等工作

教学科研项目情况

◾1. 国家自然科学基金青年基金，82001286，2021.01-2023.12，主持

◾2. 山东省自然科学青年基金，ZR2020QH112，2021/01-2023/12，主持

◾3. 山东省抗体制药协同创新中心开放课题，CIC-AD1829，2018/1-2020/12，主持

◾4. 聊城大学博士及高层次人才科研启动基金，318051827，2017/12-2020/12，主持

◾5. 聊城大学理学科研基金，318011907，2019/06-2020/12，主持

◾6.聊城大学畜牧学学科开放课题-创新项目，319312101-25，2021.08-2023.03，主持

◾7.食品科学与技术国家重点实验室开放课题，SKLF-KF-202112，2021.12-2023.12，主持

已发表SCI论文20余篇，代表性研究成果发表在 Biomacromolecules.，J Agric Food Chem.，Food Funct.，等权威期刊。

代表论文发表

1. Liu B, Zhang N*(共一) , Yang J, Sun W, Zhang R, Zheng X, Wang Z, Siebert HC, Han J. J Agric Food Chem. 2022 Feb 16;70(6):1852-1864. doi: 10.1021/acs.jafc.1c07403. Epub 2022 Feb. (SCI 一区，研究成果被评为当期封面图片论文)

2.Liu C, Zhang N*, Zhang R*, Jin L, Petridis AK, Loers G, Zheng X, Wang Z, Siebert HC. Cuprizone-Induced Demyelination in Mouse Hippocampus Is Alleviated by Ketogenic Diet. J Agric Food Chem. 2020 Oct 7;68(40):11215-11228. doi: 10.1021/acs.jafc.0c04604. Epub 2020 Sep 23. (SCI 一区)

3.Zhang N, Liu C, Jin L, Zhang R*, Wang T, Wang Q*, Chen J, Yang F, Siebert HC, Zheng X. Ketogenic Diet Elicits Antitumor Properties through Inducing Oxidative Stress, Inhibiting MMP-9 Expression, and Rebalancing M1/M2 Tumor-Associated Macrophage Phenotype in a Mouse Model of Colon Cancer. J Agric Food Chem. 2020 Oct 7;68(40):11182-11196. doi: 10.1021/acs.jafc.0c04041. (SCI 一区，研究成果被评为当期封面图片论文)

4.Zhang N, Liu C, Zhang R*, Jin L, Yin X, Zheng X*, Siebert HC, Li Y, Wang Z, Loers G, Petridis AK. Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet. Food Funct. 2020 Jun 24;11(6):5647-5663. doi: 10.1039/c9fo02944c. (SCI 一区)

5.Jin L, Liu C, Zhang N*, Zhang R*, Yan M, Bhunia A, Zhang Q, Liu M, Han J*, Siebert HC. Attenuation of Human Lysozyme Amyloid Fibrillation by ACE Inhibitor Captopril: A Combined Spectroscopy, Microscopy, Cytotoxicity, and Docking Study. Biomacromolecules. 2021 May 10;22(5):1910-1920. doi: 10.1021/acs.biomac.0c01802. Epub 2021 Apr 12. (SCI 一区)

6.Zhang N, Liu F, Li J, Sui H, Miao F, Chen T, Shao M, Zhao L, Zhang R, Zhao J*. Stability of Ebola Virus Immunoglobulin G Antibodies in Long-term Stored Samples. J Infect Dis. 2020 Aug 17;222(6):1064-1065. doi: 10.1093/infdis/jiaa040. PMID: 32073609. (SCI 二区)

7.Jin L, Gao W, Liu C, Zhang N*, Mukherjee S, Zhang R*, Dong H, Bhunia A, Bednarikova Z, Gazova Z, Liu M, Han J*, Siebert HC. Investigating the inhibitory effects of entacapone on amyloid fibril formation of human lysozyme. Int J Biol Macromol. 2020 Oct 15;161:1393-1404. doi: 10.1016/j.ijbiomac.2020.07.296. Epub 2020 Aug 1. (SCI 二区)

8.Gao W, Jin L, Liu C, Zhang N*, Zhang R*, Bednarikova Z, Gazova Z, Bhunia A, Siebert HC, Dong H*. Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism. Int J Biol Macromol. 2021 May 1;178:424-433. doi: 10.1016/j.ijbiomac.2021.02.213. Epub 2021 Mar 1. (SCI 二区)

9.Eckert T, Jährling-Butkus M, Louton H, Burg-Roderfeld M, Zhang R, Zhang N*, Hesse K, Petridis AK, Kožár T, Steinmeyer J, Schauer R, Engelhard P, Kozarova A, Hudson JW, Siebert HC*. Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms. Mar Drugs. 2021 Sep 26;19(10):542. doi: 10.3390/md19100542. (SCI 二区)

10.Zhang N, Jin L, Liu C, Zhang R*, Siebert HC, Petridis AK., Xia Z.*, Dong H*, Zheng X. An antarctic krill oil-based diet elicits neuroprotective effects by inhibiting oxidative stress and rebalancing the M1/M2 microglia phenotype in a cuprizone model for demyelination - ScienceDirect[J]. Journal of Functional Foods, 76. (SCI 二区)

11.Zhang N, Liu C, Jin L, Zhang R*, Siebert HC, Wang Z*, Prakash S, Yin X, Li J, Hou D, Sun B, Liu M. Influence of Long-Chain/Medium-Chain Triglycerides and Whey Protein/Tween 80 Ratio on the Stability of Phosphatidylserine Emulsions (O/W). ACS Omega. 2020 Mar 30;5(14):7792-7801. (SCI 三区)

12.SunW, LiuB, YangJ, WenM,  LiuG, WangS,  A.Z Muhammad, A.A Muhammad, A.Z Muhammad, A.K. Muhammad, Zhang N*.Neuroprotective Effects and Amelioration of Ethyl Esters form of Fish Oil Supplementation in Neuroinflammation in a Mouse Model of Cuprizone-Induced Demyelination.Pak Vet J, 2022, 42(1): 25-32. (SCI 四区)

专利

（1）一种磷脂酰丝氨酸乳剂的制备方法，中国专利，申请号CN2019107064064。

（2）一种用于预防和/或治疗髓鞘脱失疾病的生酮饮食组合物及其制备方法和用途，中国专利，申请号CN20201068002.7。

（3）一种含有中药活性成分的中链甘油三酯生酮饮食组合物及其制备方法和应用，中国专利，申请号CN202010722199.4。