博士 / 副教授/硕士生导师

  聊城大学“光岳英才”和“光岳新秀”人才支持计划

  聊城大学生物制药研究院“人才支持计划”

  聊城市高新区“3111”工程高端人才

  邮箱：zhaoyanna@lcu.edu.cn

研究方向：

注射/眼用纳米给药系统；难溶性药物增溶；固体分散体；热熔挤出技术

教育及工作经历：

• 2021/01-至今，聊城大学，生物制药研究院，副教授
• 2016/07-2021/01，聊城大学，生物制药研究院，讲师
• 2011/09-2016/07，中国医学科学院＆北京协和医学院，医学博士
• 2007/09-2011/07，山东大学，理学学士 

教学科研项目情况：

§ 国家自然科学基金委员会，面上项目，22073039，靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究，2021/01-2024/12，参与

§ 国家自然科学基金委员会，面上项目，32172901，基于JAK/STAT通路研究硒化刺五加多糖对肉鸡肠道巨噬细胞极化的干预作用，2022/01-2025/12，参与

§ 山东省自然科学基金联合基金项目，ZR2022LSW018，靶向眼新生血管的非侵入性纳米递送系统的构建及其多靶点协同逆转眼新生血管疾病的研究，2023/01-2025/12，主持

§ 山东省自然科学基金项目，ZR2017BH065，基于新型“高效稳定剂”，集光疗、化疗于一体的靶向双功能性纳米粒的构建及评价， 2017/08-2019/12，主持

§ 山东省高等学校科技计划项目，J17KA234，集光疗-化疗于一体的双功能性无载体纳米粒的设计评价及产品开发，2017/07-2019/07，主持

§ 山东省抗体制药协同创新中心开放课题，CIC-AD1831，基于白蛋白构建的光疗-化疗双功能性纳米粒用于肿瘤的协同治疗，2018/01-2020/12，主持

§ 横向课题，K20LD39，高稳定性肿瘤肠内全营养乳剂检测方法开发和样品检测，2020/11-2022/11，主持

§ 聊城大学研究生教育教学改革研究项目，“产学研平台”建设下的研究生《现代药理学》课程教学改革与实践，2019/10-2021/10，主持

代表性论文：

  （1）Qingran Guan, Yinglan Li, Huaizhen Zhang, Sisi Liu, Zhuang Ding, Zhiping Fan, Qingpeng Wang, Zhengping Wang, Jun Han, Min Liu^*, and Yanna Zhao^*. Laser-responsive multi-functional nanoparticles for efficient combinational chemo-photodynamic therapy against breast cancer. Colloids Surf B Biointerfaces, 2022, 216, 112574. (SCI 2区)

（2）Qingran Guan, Qisan Ma, Yanna Zhao*, Xinxin Jiang, Huaizhen Zhang, Min Liu, Zhengping Wang, Jun Han. Cellulose derivatives as effective recrystallization inhibitor for ternary ritonavir solid dispersions: In vitro-in vivo evaluation. Carbohydr Polym, 2021, 273, 118562. (SCI 1区, TOP)

（3）Xinxin Jiang, Yanna Zhao*, Qingran Guan, Shanshan Xiao, Weimiao Dong, Shipeng Lian, Huaizhen Zhang, Min Liu, Zhengping Wang, Jun Han*. Amorphous solid dispersions of cyclosporine A with improved bioavailability prepared via hot melt extrusion: Formulation, physicochemical characterization, and in vivo evaluation. Eur J Pharm Sci, 2022, 168, 106036. (SCI 2区)

（4）Yanna Zhao, Xinxin Jiang, Qisan Ma, Yuping Zhao, Huaizhen Zhang, Qingpeng Wang, Zhuang Ding, Min Liu*, Zhengping Wang, Jun Han. High payload nanoparticles composed of 7-ethyl-10-hydroxycamptothecin and chlorin e6 for synergistic chemo-photodynamic combination therapy. Dyes Pigments, 2021, 184, 108819. (SCI 2区)

（5）Yanna Zhao, Chang Cai, Min Liu*, Yuping Zhao, Yushu Wu, Zhiping Fan, Zhuang Ding, Huaizhen Zhang, Zhengping Wang, Jun Han. Drug-binding albumins forming stabilized nanoparticles for co-delivery of paclitaxel and resveratrol: In vitro/in vivo evaluation and binding properties investigation. Int J Biol Macromol, 2020, 153, 873-882. (SCI 1区, TOP)

（6）Yanna Zhao*, Yuping Zhao, Qisan Ma, Huaizhen Zhang, Yinglin Liu, Jingyi Hong, Zhuang Ding, Min Liu*, Jun Han. Novel carrier-free nanoparticles composed of 7-ethyl-10-hydroxycamptothecin and chlorin e6: Self-assembly mechanism investigation and in vitro/in vivo evaluation, Colloids Surf B Biointerfaces, 2020, 188, 110722. (SCI 2区)

（7）Qisan Ma, Yanna Zhao*, Qingran Guan, Yuping Zhao, Huaizhen Zhang, Zhuang Ding, Qingpeng Wang, Yushu Wu, Min Liu & Jun Han* Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy, Drug Delivery, 2020, 27:1, 1656-1666. (SCI 2区)

（8）Yuping Zhao#, Yanna Zhao#,*, Qisan Ma, Bin Sun, Qingpeng Wang, Zhuang Ding, Huaizhen Zhang, Xiuling Chu, Min Liu, Zhengping Wang, Jun Han*. Carrier-Free, Dual-Functional Nanorods via Self-Assembly of Pure Drug Molecules for Synergistic Chemo-Photodynamic Therapy. Int J Nanomed, 2019, 14, 8665-8683. (SCI 2区)

（9）Yanna Zhao, Chang Cai, Min Liu*, Yuping Zhao, Wenxin Pei, Xiuling Chu, Huaizhen Zhang, Zhengping Wang, Jun Han*. An organic solvent-free technology for the fabrication of albumin-based paclitaxel nanoparticles for effective cancer therapy. Colloids Surf B Biointerfaces, 2019, 183, 110394. (SCI 2区)

（10）Yanna Zhao, Xuemei Xie, Yuping Zhao, Yan Gao, Chang Cai, Qinxiu Zhang, Zhuang Ding, Zhiping Fan, Huaizhen Zhang, Min Liu*, Jun Han*. Effect of plasticizers on manufacturing ritonavir/copovidone solid dispersions via hot-melt extrusion: Preformulation, physicochemical characterization, and pharmacokinetics in rats. Eur J Pharm Sci, 2019, 127, 60–70. (SCI 2区)

（11）Qinxiu Zhang, Yanna Zhao*, Yuping Zhao, Zhuang Ding, Zhiping Fan, Huaizhen Zhang, Min Liu, Zhengping Wang, Jun Han*. Effect of HPMCAS on recrystallization inhibition of nimodipine solid dispersions prepared by hot-melt extrusion and dissolution enhancement of nimodipine tablets. Colloids Surf B Biointerfaces, 2018, 172, 118–126. (SCI 2区)

（12）Yifei Guo#, Yanna Zhao#, Ting Wang, Ran Li, Meihua Han, Zhengqi Dong, Chunyan Zhu*, and Xiangtao Wang*. Hydroxycamptothecin Nanorods Prepared by Fluorescently Labeled Oligoethylene Glycols (OEG) Codendrimer: Antitumor Efficacy in Vitro and in Vivo. Bioconjugate Chem, 2017, 28 (2), 390–399. (SCI 2区)

（13）Yifei Guo#, Yanna Zhao#, Ting Wang, Shuang Zhao, Hanhong Qiu, Meihua Han and Xiangtao Wang*. Honokiol nanoparticles stabilized by oligoethylene glycols codendrimer: in vitro and in vivo investigations. J Mater Chem B, 2017, 5, 697-706. (SCI 2区)