博士 / 副教授/硕士生导师

  聊城大学“光岳英才”和“光岳新秀”人才支持计划

  聊城大学生物制药研究院“人才支持计划”

  聊城市高新区“3111”工程高端人才

  邮箱：zhaoyanna@lcu.edu.cn

研究方向：

长期从事药剂学专业领域的研究，主要致力于新型抗肿瘤药物纳米递送系统、眼用纳米给药系统等创新制剂的开发，以及难溶性药物增溶技术、过饱和溶液相分离行为等的研究工作。

教育及工作经历：

• 2021/01-至今，聊城大学，生物制药研究院，副教授
• 2016/07-2021/01，聊城大学，生物制药研究院，讲师
• 2011/09-2016/07，中国医学科学院＆北京协和医学院，医学博士
• 2007/09-2011/07，山东大学，理学学士 

教学科研项目情况：

§  靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究，国家自然科学基金面上项目，2021-2024，参与

§  靶向眼新生血管的非侵入性纳米递送系统的构建及其多靶点协同逆转眼新生血管疾病的研究，山东省自然科学基金联合基金，2023-2025，主持

§  基于新型“高效稳定剂”，集光疗、化疗于一体的靶向双功能性纳米粒的构建及评价，山东省自然科学基金，2017-2019，主持

§  基于白蛋白构建的光疗-化疗双功能性纳米粒用于肿瘤的协同治疗，山东省抗体制药协同创新中心开放课题，2018-2020，主持

§  高稳定性肿瘤肠内全营养乳剂检测方法开发和样品检测，横向课题，2020-2022，主持

代表性论文：

（1）Yinglan Li, Qipeng Wei, Jianshuo Su, Huaizhen Zhang, Zhiping Fan, Zhuang Ding, Min Wen, Min Liu, Yanna Zhao*. Encapsulation of astaxanthin in OSA-starch based amorphous solid dispersions with HPMCAS-HF/Soluplus® as effective recrystallization inhibitor, Int J Biol Macromol, 2024, 279, Part 1, 135421.

（2）Qingran Guan1, Jianshuo Su1, Yinglan Li, Huaizhen Zhang, Zhuang Ding, Qingpeng Wang, Shilei Ji, Jun Han, Min Liu, and Yanna Zhao*. Near-Infrared Laser-Responsive Erythrocyte Membrane Camouflaged Nanoparticles for Chemo-Photodynamic Therapy of Breast Cancer. ACS Applied Nano Materials, 2024, 7 (11), 13785-13798.

（3）Yinglan Li, Jie Xu, Qingran Guan, Huaizhen Zhang, Zhuang Ding, Qingpeng Wang, Zhengping Wang, Jun Han, Min Liu*, Yanna Zhao*. Impact of hypromellose acetate succinate and Soluplus® on the performance of β-carotene solid dispersions with the aid of sorbitan monolaurate: In vitro-in vivo comparative assessment, Int J Biol Macromol, 2023, 253, 126639.

（4）Yinglan Li, Qingran Guan, Jie Xu, Huaizhen Zhang, Sisi Liu, Zhuang Ding, Qingpeng Wang, Zhengping Wang, Min Liu, Yanna Zhao*. Comparative study of cyclosporine A liposomes and emulsions for ophthalmic drug delivery: Process optimization through response surface methodology (RSM) and biocompatibility evaluation, Colloid Surface B, 2023, 225, 113267.

（5）Qingran Guan, Yinglan Li, Huaizhen Zhang, Sisi Liu, Zhuang Ding, Zhiping Fan, Qingpeng Wang, Zhengping Wang, Jun Han, Min Liu^*, and Yanna Zhao^*. 

Laser-responsive multi-functional nanoparticles for efficient combinational chemo-photodynamic therapy against breast cancer. Colloids Surf B Biointerfaces, 2022, 216, 112574.

（6）Xinxin Jiang, Yanna Zhao*, Qingran Guan, Shanshan Xiao, Weimiao Dong, Shipeng Lian, Huaizhen Zhang, Min Liu, Zhengping Wang, Jun Han*. Amorphous solid dispersions of cyclosporine A with improved bioavailability prepared via hot melt extrusion: Formulation, physicochemical characterization, and in vivo evaluation. Eur J Pharm Sci, 2022, 168, 106036.

（7）Qingran Guan, Qisan Ma, Yanna Zhao*, Xinxin Jiang, Huaizhen Zhang, Min Liu, Zhengping Wang, Jun Han. Cellulose derivatives as effective recrystallization inhibitor for ternary ritonavir solid dispersions: In vitro-in vivo evaluation. Carbohydr Polym, 2021, 273, 118562.

（8）Yanna Zhao, Xinxin Jiang, Qisan Ma, Yuping Zhao, Huaizhen Zhang, Qingpeng Wang, Zhuang Ding, Min Liu*, Zhengping Wang, Jun Han. High payload nanoparticles composed of 7-ethyl-10-hydroxycamptothecin and chlorin e6 for synergistic chemo-photodynamic combination therapy. Dyes Pigments, 2021, 184, 108819.

（9）Yanna Zhao, Chang Cai, Min Liu*, Yuping Zhao, Yushu Wu, Zhiping Fan, Zhuang Ding, Huaizhen Zhang, Zhengping Wang, Jun Han. Drug-binding albumins forming stabilized nanoparticles for co-delivery of paclitaxel and resveratrol: In vitro/in vivo evaluation and binding properties investigation. Int J Biol Macromol, 2020, 153, 873-882.

（10）Yanna Zhao*, Yuping Zhao, Qisan Ma, Huaizhen Zhang, Yinglin Liu, Jingyi Hong, Zhuang Ding, Min Liu*, Jun Han. Novel carrier-free nanoparticles composed of 7-ethyl-10-hydroxycamptothecin and chlorin e6: Self-assembly mechanism investigation and in vitro/in vivo evaluation, Colloids Surf B Biointerfaces, 2020, 188, 110722.

（11）Qisan Ma, Yanna Zhao*, Qingran Guan, Yuping Zhao, Huaizhen Zhang, Zhuang Ding, Qingpeng Wang, Yushu Wu, Min Liu & Jun Han* Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy, Drug Delivery, 2020, 27:1, 1656-1666.