博士/副教授/研究生导师/注册营养师(RD) 

 聊城大学“光岳英才二层次”人才支持计划

 邮箱：woshiwenmin@163.com

2017.07-至今       聊城大学 生物制药研究院

2012.09-2017.06    中国海洋大学， 食品科学博士

2008.09-2012.06    济南大学，理学学士     

主要从事食品功效成分挖掘与分子营养学研究：

主要研究内容包括，膳食营养组分及营养性生酮对神经退行性疾病及代谢综合征的干预机制，食品营养因子对细胞内信号通路、线粒体功能的影响等方面的研究。近期主要致力于：（1）基于肠-脑轴探究食品功效成分对中枢神经系统疾病（如认知障碍、阿尔茨海默症、睡眠障碍等）的改善作用及分子用机制；（2）犬猫精准营养需求研究、犬猫源益生菌挖掘及产业化。

1. 山东省营养学会特殊食品专委会委员

2. 山东省营养学会营养科学研究专委会常务委员

3. 乖宝宠物食品集团股份有限公司，科技副总

4. 目前担任Food Funct., MDPI旗下相关领域期刊审稿人。

1. 山东省自然科学青年基金，ZR2021QH022，2022/01-2024/12，主持。

2. 山东省抗体制药协同创新中心开放课题，CIC-AD1842，2018/1-2020/12，主持。

3. 山东省重点研发计划（医用食品专项计划），2018YYSP008，2018.01-2020.12 参与。

4. 聊城大学博士及高层次人才科研启动基金，318051827，2017/12-2020/12，主持。

5. 校企合作项目，318/K20LD0901，2020/01-2021/12；318/K22LD52，2022/01-2023/12，318/K24LD105，主持。

6. 聊城大学畜牧学学科开放课题-创新项目，319462207-24，2023.01-2023.12，主持。

已公开发表SCI论文20余篇，申请发明专利2项。代表性研究成果发表在 J Agric Food Chem.，Food Funct.，ood Science and Human Wellness，Molecular Nutrition & Food Research.等权威食品营养期刊。近5年发表代表性文章如下：

1. Yang, Y., Wang, X.,Chen, L.,Zhang, N.,Ji S., ;Wang, Z., Han, J., Wang, Y.; Wen, M., (2024). Exogenous ketogenic supplements can mitigate the susceptibility to Alzheimer’s disease induced by chronic sleep deprivation:emerging role of Sirt1 in ferroptosis. Food Science and Human Wellness, 2024, https://doi.org/10.26599/FSHW.2024.9250067 (中科院一区，IF=5.6)
2. Chen, L., Yang, Y., Zhang, N., Che, H., Wang, Z., Han, J., & Wen, M. (2024). DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis.Free radical biology & medicine,225, 654–664. (中科院二区，IF=7.1)

[3] Yang, Y.; Chen, L.; Zhang, N.; Zhao, Y.; Che, H.; Wang, Y.; Zhang, T.; Wen, M., DHA and EPA alleviate epileptic depression in PTZ-treated young mice model by inhibiting neuroinflammation through regulating microglial M2 polarization and improving mitochondrial metabolism. Antioxidants (Basel, Switzerland) 2023, 12 (12).(中科院二区，IF=7)

[4] Yang, Y.; Wang, X.; Chen, L.; Wang, S.; Han, J.; Wang, Z.; Wen, M., A Compared study of eicosapentaenoic acid and docosahexaenoic acid in improving seizureiInduced cognitive deficiency in a pentylenetetrazol-kindling young mice Model. Marine Drugs 2023, 21 (9).(中科院二区，IF=5.4)

[5]Wang X, Yang, Y, Xiao A, Zhang N, Miao M, Wang Z, Han J, Wen M. A comparative study of the effect of a gentle ketogenic diet containing medium-chain or long-chain triglycerides on chronic sleep deprivation-induced cognitive deficiency. Food & Function. 2022, 13(4), 2283–2294. （中科院一区, IF=6.1）

[6] Xueyan Wang; Aiai Xiao; Yueqi Yang; Yingcai Zhao; Cheng Cheng Wang; Yuming Wang; Jun Han;Zhengping Wang; Min Wen .Inside Front Cover: DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-Actions in a Pentylenetetrazole‐Induced Kindling Model in Mice, Molecular Nutrition & Food Research. 2022, 66(22): 2270061（中科院二区，封面文章）

[7] Yueqi Yang; Xueyan Wang; Aiai Xiao; Jun Han; Zhengping Wang; Min Wen M. Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer’s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway, Frontiers in Aging Neuroscience. 2022, 14: 998292-998304（中科院二区，IF=4.8）

[8]Wen M, Zhao Y, Shi H, Wang C, Zhang T, Wang Y, Xue C. Short-term supplementation of DHA as phospholipids rather than triglycerides improve cognitive deficits induced by maternal omega-3 PUFA deficiency during the late postnatal stage. Food & Function. 2021, 21;12(2):564-572.（中科院一区，IF=6.1）

[9]Wen M, Ding L, Zhang L, Zhang T, Teruyoshi Y, Wang Y, Xue C. Eicosapentaenoic Acid-Enriched Phosphatidylcholine Mitigated Aβ1-42-Induced Neurotoxicity via Autophagy-Inflammasome Pathway. Journal of Agricultural and Food Chemistry. 2019, 11;67(49):13767-13774.（中科院一区，IF=6.1）

[10]Wen M, Ding L, Zhang L, Cong P, Zhang T, Xu J, Chang Y, Wang Y, Xue C . A comparative study of eicosapentaenoic acid enriched phosphatidylcholine and ethyl ester in improving cognitive deficiency in Alzheimer's disease model rats. Food & Function. 2018, 25;9(4):2184-2192.（中科院一区，IF=6.1）

申请专利2项：

1. 一种猫乳源戊糖片球菌M9及其应用（CN202411544011.6）
2. 一种猫乳源乳酸片球菌M22及其应用（CN202411544012.0）