博士/副教授/研究生导师/注册营养师(RD) 

 聊城大学“光岳新秀”人才支持计划

 邮箱：woshiwenmin@163.com

2017.07-至今       聊城大学 生物制药研究院

2012.09-2017.06    中国海洋大学， 食品科学博士

2008.09-2012.06    济南大学，理学学士     

1.营养相关疾病的分子营养学研究。

2.食品成分应对老龄化健康问题的研究。

3.食品活性成分功效评价研究。

近期主要集中在：(1)食品功效成分对神经退行性疾病（如认知障碍、AD、睡眠障碍等）的预防及改善作用，并明确其作用机制；(2)伴侣动物（犬猫）精准营养需求研究。

1.山东省自然科学青年基金，ZR2021QH022，2022/01-2024/12，主持

2.山东省抗体制药协同创新中心开放课题，CIC-AD1842，2018/1-2020/12，主持

3.山东省重点研发计划（医用食品专项计划），2018YYSP008，2018.01-2020.12 参与

4.聊城大学博士及高层次人才科研启动基金，318051827，2017/12-2020/12，主持

5.校企合作项目，318/K20LD0901，2020/01-2021/12；318/K22LD52，2022/01-2023/12，主持

6.聊城大学畜牧学学科开放课题-创新项目，319462207-24，2023.01-2023.12，主持

已发表SCI论文20余篇，代表性研究成果发表在 J Agric Food Chem.，Food Funct.， Molecular Nutrition & Food Research.等权威营养期刊。近五年发表文章如下：

[1]Yang, Y.; Chen, L.; Zhang, N.; Zhao, Y.; Che, H.; Wang, Y.; Zhang, T.; Wen, M., DHA and EPA alleviate epileptic depression in PTZ-treated young mice model by inhibiting neuroinflammation through regulating microglial M2 polarization and improving mitochondrial metabolism. Antioxidants (Basel, Switzerland) 2023, 12 (12).(中科院二区，IF=7)

[2] Yang, Y.; Wang, X.; Chen, L.; Wang, S.; Han, J.; Wang, Z.; Wen, M., A Compared study of eicosapentaenoic acid and docosahexaenoic acid in improving seizureiInduced cognitive deficiency in a pentylenetetrazol-kindling young mice Model. Marine Drugs 2023, 21 (9).(中科院二区，IF=5.4)

[3]Wang X, Yang, Y, Xiao A, Zhang N, Miao M, Wang Z, Han J, Wen M. A comparative study of the effect of a gentle ketogenic diet containing medium-chain or long-chain triglycerides on chronic sleep deprivation-induced cognitive deficiency. Food & Function. 2022, 13(4), 2283–2294. （中科院一区, IF=6.1）

[4] Xueyan Wang; Aiai Xiao; Yueqi Yang; Yingcai Zhao; Cheng Cheng Wang; Yuming Wang; Jun Han;Zhengping Wang; Min Wen .Inside Front Cover: DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-Actions in a Pentylenetetrazole‐Induced Kindling Model in Mice, Molecular Nutrition & Food Research. 2022, 66(22): 2270061（中科院二区，封面文章）

[5] Yueqi Yang; Xueyan Wang; Aiai Xiao; Jun Han; Zhengping Wang; Min Wen M. Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer’s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway, Frontiers in Aging Neuroscience. 2022, 14: 998292-998304（中科院二区，IF=4.8）

[6]Wen M, Zhao Y, Shi H, Wang C, Zhang T, Wang Y, Xue C. Short-term supplementation of DHA as phospholipids rather than triglycerides improve cognitive deficits induced by maternal omega-3 PUFA deficiency during the late postnatal stage. Food & Function. 2021, 21;12(2):564-572.（中科院一区，IF=6.1）

[7]Wen M, Ding L, Zhang L, Zhang T, Teruyoshi Y, Wang Y, Xue C. Eicosapentaenoic Acid-Enriched Phosphatidylcholine Mitigated Aβ1-42-Induced Neurotoxicity via Autophagy-Inflammasome Pathway. Journal of Agricultural and Food Chemistry. 2019, 11;67(49):13767-13774.（中科院一区，IF=6.1）

[8]Wen M, Ding L, Zhang L, Cong P, Zhang T, Xu J, Chang Y, Wang Y, Xue C . A comparative study of eicosapentaenoic acid enriched phosphatidylcholine and ethyl ester in improving cognitive deficiency in Alzheimer's disease model rats. Food & Function. 2018, 25;9(4):2184-2192.（中科院一区，IF=6.1）

[9]Zhou M, Ding L, Wen M, Che H, Huang J, Zhang T, Xue C, Mao X, Wang Y. Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet. Journal of Nutritional Biochemistry. 2018, 59:64-75.

[10]Li Q, Wu F, Wen M, Yanagita T, Xue C, Zhang T, Wang Y. The Protective Effect of Antarctic Krill Oil on Cognitive Function by Inhibiting Oxidative Stress in the Brain of Senescence-Accelerated Prone Mouse Strain 8 (SAMP8) Mice. Journal of Food Science. 2018,83:543-551.