博士/讲师

邮箱：Yuan1072165059@163.com

联系电话：19563560785

通讯地址：山东省聊城市湖南路1号

邮政编码：252059

教育及工作经历：

 2022.10-至今     聊城大学，生物制药研究院，讲师

 2019.05-2022.07  卡梅里诺大学，化学、制药科学与生物技术学院，化学科学，博士学位

 2015.09-2018.06  聊城大学，化学与化工学院，物理化学，硕士学位

 2011.09-2015.06  菏泽学院，化学与化工学院，化学，学士学位

研究方向：化学热力学、有机合成

 1. 生物大分子与具有生物活性小分子之间的相互作用；

 2. 抗肺结核药物的绿色合成及其生物活性探究；

科研项目情况：

 聊城大学博士及高层次人才科研启动基金，318052262，2023.01.01-2025.12.31，主持。

论文发表：

1. L.X. Yuan, L. Kachalova, M.E.I. Khan, R. Ballini, M. Petrini, A. Palmieri, Overcoming the usual reactivity of b‑nitroenones: Synthesis of polyfunctionalized homoallylic alcohols and conjugated nitrotriene systems, J. Org. Chem. 88 (2023) 4770−4777. https://doi.org/10.1021/acs.joc.2c02669. (SCI 2区)

2. L.X. Yuan, M. Liu, Y.F. Ren, Y.H. Zhu, Binding effects of piceatannol and oxyresveratrol on the structural and functional properties of soy protein isolate, J. Mol. Struct. 1288 (2023) 135805. https://doi.org/10.1016/j.molstruc.2023.135805. (SCI 2区)

3. M.E. I. Khan, L.X. Yuan, M. Petrini, A. Palmieri, A new one-pot synthesis of 3,6-disubstituted pyridazines starting from β-nitro-β,γ-unsaturated ketones, Synthesis 55 (2023) 3204−3208. https://doi.org/10.1055/a-2114-7673. (SCI 4区)

4. J. Li, X.J. Li, L. Sun, X.S. Wang, L.X. Yuan, L.G. Wu, X. Liu, Y.L. Wang, Syntheses of triangular gold complexes and their applications in hydroamination reaction, Eur. J. Inorg. Chem. 2021 (2021) 4230−4237. https://doi.org/10.1002/ejic.202100572. (SCI 3区)

5. L.X. Yuan, A. Palmieri, M. Petrini, Synthesis of unsymmetrical bisindolylmethanes by reaction of indolylmagnesium bromides with sulfonyl indoles, Adv. Synth. Catal. 362 (2020) 1509–1513. https://doi.org/10.1002/adsc.201901357. (SCI 2区)

6. L.X. Yuan, M. Liu, Y.B. Shi, H. Yan, J. Han, L.Y. Liu, Effect of (–)-epicatechin-3-gallate and (–)-epigallocatechin-3-gallate on the binding of tegafur to human serum albumin as determined by spectroscopy, isothermal titration calorimetry, and molecular docking, J. Biomol. Struct. Dyn. 37 (2019) 2776–2788. https://doi.org/10.1080/07391102.2018.1505550. (SCI 3区)