博士 / 讲师

邮箱：wangchao911002@163.com

通讯地址：山东省聊城市湖南路1号

邮政编码：252059

教育及工作经历：

2022.07-至今     聊城大学，生物制药研究院，讲师

2018.07-2022.06  南开大学，化学学院，高分子化学与物理，博士学位

2015.09-2018.06  中国石油大学（华东），化工学院，生物工程，硕士学位

2011.09-2015.06  青岛农业大学，生命科学学院，生物技术，学士学位

研究方向：

新型功能性有机/高分子荧光材料的构建及其生物医药应用：

1. 环境响应型光敏剂的设计、合成及生物活性研究；

2. 极性敏感型荧光探针的设计、合成及生物传感研究；

3. 基于天然蛋白的药物靶向递送体系的构建及药物化学研究。

科研项目情况：

1. 聊城大学博士及高层次人才科研启动基金，318052260，2013.12.31-2025.12.31，主持。

2. 山东省自然科学基金青年项目，R2023QB269，2024.01.01-2026.12.31，主持。

发表论文：

13.   Jiaxin Wang^#, Liang Tian^#, Kaiyu Wu, Chao Wang, and Chunlei Zhu*. Reconstituting Low-Density Lipoprotein with NIR-Absorbing Organic Photothermal Agents for Targeted Killing of Cancer Cells. Macromol. Rapid Commun. 2023, 2300395. (SCI二区) DOI: 10.1002/marc.202300395.

12.   Shuyi Lv, Chao Wang, Ke Xue, Jiaxin Wang, Ming-hui Xiao, Zhencheng Sun, Lei Han, Linqi Shi, and Chunlei Zhu*. Activated alkyne-enabled turn-on click bioconjugation with cascade signal amplification for ultrafast and high-throughput antibiotic screening. Proc. Natl. Acad. Sci. U.S.A., 2023, 120, e2302367120. (SCI一区，Top) DOI: 10.1073/pnas.2302367120.

11.   Binghong He^#, Chao Wang^#, Fuping Wang, Liang Tian, Haitao Wang, Chunling Fu, Jin Liu, Chao Xi, Chunlei Zhu,* and Qiong Yang*. Differentiation Therapy for Murine Myelofibrosis Model with MLN8237 Loaded Low-density Lipoproteins. J. Control. Release, 2023, 356, 554–566. (SCI一区，Top)  DOI: 10.1016/j.jconrel.2023.03.024.

10.   Chao Wang^#, Xianhao Zhao^#, Kaiyu Wu, Shuyi Lv, and Chunlei Zhu*. A Ratiometric Organic Fluorescent Nanogel Thermometer for Highly Sensitive Temperature Sensing. Biosensors, 2022, 12, 702. (SCI二区) DOI: 10.3390/bios12090702.

9.    Chao Wang, Jiaxin Wang, Ke Xue, Ming-hui Xiao, Kaiyu Wu, Shuyi Lv, Boyi Hao, and Chunlei Zhu*. Polarity-Sensitive Fluorescent Probe for Reflecting the Packing Degree of Bacterial Membrane Lipids. Anal. Chem., 2022, 94, 3303–3312. (SCI一区，Top) DOI: 10.1021/acs.analchem.1c05268.

8.    Boyi Hao, Jiaxin Wang, Chao Wang, Ke Xue, Ming-hui Xiao, Shuyi Lv, and Chunlei Zhu*. Bridging D‒A type photosensitizers with the azo group to boost intersystem crossing for efficient photodynamic therapy. Chem. Sci., 2022, 13, 4139–4149. (SCI一区，Top) DOI: 10.1039/D2SC00381C.

7.    Ke Xue, Chao Wang, Jiaxin Wang, Shuyi Lv, Boyi Hao, Chunlei Zhu,* and Ben Zhong Tang*. A Sensitive and Reliable Organic Fluorescent Nanothermometer for Noninvasive Temperature Sensing. J. Am. Chem. Soc., 2021, 143, 14147–14157. (SCI一区，Top) DOI: 10.1021/jacs.1c04597.

6.    Chao Wang, Xianhao Zhao, Haoyu Jiang, Jiaxin Wang, Weixiu Zhong, Ke Xue, and Chunlei Zhu*. Transporting mitochondrion-targeting photosensitizers into cancer cells by low-density lipoproteins for fluorescence-feedback photodynamic therapy. Nanoscale, 2021, 13, 1195–1205. (SCI一区，Top)  DOI: 10.1039/D0NR07342C.

5.    Xiaoqiang Wang, Shixin Li, Chao Wang, Christopher J. Mujuni, Tongtao Yue*, and Fang Huang*. Supramolecular Construction of Biohybrid Nanozymes Based on the Molecular Chaperone GroEL as a Promiscuous Scaffold. ACS Biomater. Sci. Eng., 2020, 6, 833–841. (SCI二区) DOI: 10.1021/acsbiomaterials.9b00997.

4.    Xiaoqiang Wang*, Haiyan Sun, Chengkun Liu and Chao Wang. A hemin-functionalized GroEL nanocage as an artificial peroxidase and its application in chromogenic detection. Anal. Methods, 2019, 11, 2197–2203. (SCI三区) DOI: 10.1039/C9AY00201D.

3.    Xiaoqiang Wang^#, Chao Wang^#, Baomei Xu, Junting Wei, Yang Xiao, Fang Huang*. Adsorption of intrinsically disordered barnacle adhesive proteins on silica surface. Appl. Surf. Sci., 2018, 427, 942–949. (SCI一区，Top) DOI: 10.1016/j.apsusc.2017.08.108.

2.    Xiaoqiang Wang^#, Chao Wang^#, Meihong Pan, Junting Wei, Fuping Jiang, Rongsheng Lu, Xuan Liu, Yihui Huang, and Fang Huang*. Chaperonin-Nanocaged Hemin as an Artificial Metalloenzyme for Oxidation Catalysis. ACS Appl. Mater. Interfaces, 2017, 9, 30, 25387–25396. (SCI一区，Top) DOI: 10.1021/acsami.7b08963.

1.    Xiaoqiang Wang^#, Yang Xiao^#, Chao Wang^#, Jianjie Niu, Jing Ma, Haodong Wang, Xinwei Li, Xue Chen, Fang Huang*. Hierarchical interfacial structuring of the calcareous base of the barnacle Balanus albicostatus over different length scales. Mater. Chem. Phys., 2017, 192, 48–57. (SCI三区) DOI: 10.1016/j.matchemphys.2017.01.053.